浩瀚色譜（山東）應用技術開發(fā)有限公司,是齊魯大地一家從事色譜儀器技術開發(fā)，技術推廣的技術型企業(yè)，研發(fā)出多款新型產(chǎn)品。（一）專用色譜柱：1.氯乙suan直接進樣分析專用柱2.氯化氫直接進樣分析專用柱3.氯QI直接進樣分析專用柱4.四氟化硅直接進樣分析專用柱5.六氟二甲基硅醚分析專用柱6.氨氣直接進樣分析專用柱（二）痕量分析專用氣相色譜儀：1.高純氣體中痕量水（ppb級）分析專用氣相色譜儀2.純苯中痕量噻吩（ppb級）分析專用氣相色譜儀（三）防腐型氣相色譜儀，并成功應用于氟氣，氟化氫，氯QI，氨氣，酰氯，氯化氫，三氯氫硅，四氟化硅，氯YI酸，氯HUA亞砜，硫化物，二氯化硫等腐蝕性物質檢測，產(chǎn)品遍布各個行業(yè)及地區(qū)，其中不乏有大型央企---中石油，中儲糧，秦山核電站，中紡集團等，部分出口。

公司主要業(yè)務

1.通用氣相色譜儀生產(chǎn)銷售：氫火焰檢測器氣相色譜儀，熱導檢測器氣相色譜儀，火焰光度檢測器氣相色譜儀，氮磷檢測器氣相色譜儀，電子捕獲檢測器氣相色譜儀。

2.便攜式氣相色譜儀，在線氣相色譜儀生產(chǎn)銷售。

3.專用氣相色譜儀研發(fā)制造：氧化鋯檢測器氣相色譜儀，氦離子檢測器氣相色譜儀，氬離子檢測器氣相色譜儀等。

4.防腐氣相色譜儀

5.二維，多維氣相色譜儀

6.高效液相色譜儀

7.實驗室純水機，頂空進樣器，自動進樣器，熱解析儀，氮氫空發(fā)生器，色譜耗材（色譜柱，石墨墊，穩(wěn)壓閥，壓蓋鉗，頂空瓶，7725進樣閥等），分光光度計，電子天平，水分測定儀，干燥箱，離心機，玻璃儀器，化學試劑等整套實驗室設備生產(chǎn)銷售。

8.提供技術轉讓，建立分析方法。

9.從事舊色譜以舊換新的業(yè)務。

10.色譜柱研制，定做。

11.承接樣品的檢測業(yè)務。

12.承接國內(nèi)外色譜儀器的維修，改裝業(yè)務。

浩瀚色譜（山東）應用技術開發(fā)有限公司，以客戶為中心，想客戶所想，銷售的不僅僅是產(chǎn)品，重要的是幫助客戶解決問題，架起心靈溝通的橋梁。

名稱：填充柱
固定相：苯乙烯-二乙烯苯共聚物

規(guī)格：2m*3mm

粒度：60-80目

型號：GDX-101
儀器：島津2014

應用：藥典2015溶劑殘留測定：甲磺酸左氧氟沙星中有機溶劑殘留；頭孢菌素類抗生素殘留溶劑的測定

隨著醫(yī)藥工業(yè)技術的提高以及人民健康水平的提高。各國藥典對藥物質量指標提出愈來愈高的要求和標準。

95版中國藥典收入了氣相色譜法測定有機溶劑殘留量。但不同溶劑采用不同柱溫條件測定,甚是麻煩。美國藥典可同時測定多種有機溶劑殘留,但條件苛刻,操作繁復。

為此,浩瀚色譜（山東）應用技術開發(fā)有限公司并研究提出了同時測定藥物多種有機溶劑殘留量的氣相色譜法。測定條件是:GDX-101填充柱,柱溫150℃,進樣口溫度210℃。氣體流速氮氣50ml/空氣0.5kg/cm~2,氫氣0.5kg/cm~2,檢測器為氫火焰,量程10~3,數(shù)據(jù)處理機衰減值為,進樣濃度按藥典規(guī)定配制,進樣量為3μl。結果表明:可以同時測定多種溶劑,方法簡便、準確、快速、能滿足藥典要求。


2015版藥典溶劑殘留測定填充柱 測試譜圖：



Packed column for determination of solvent residue in Pharmacopoeia of 2015 edition
Packed column for determination of solvent residue in the 2015 Pharmacopoeia Details:

Name: Packed column
Stationary phase: styrene-divinylbenzene copolymer

Specification: 2m*3mm

Granularity: 60-80 mesh

Model: GDX-101

Application: Pharmacopoeia 2015 solvent residue determination: organic solvent residue in levofloxacin mesylate; determination of cephalosporin antibiotic residue solvent

With the improvement of pharmaceutical industry technology and the improvement of people's health. Pharmacopoeias of various countries have put forward higher and higher requirements and standards for drug quality indicators.

The 95th edition of the Chinese Pharmacopoeia includes gas chromatography for the determination of residual organic solvents. However, it is very troublesome to use different column temperature conditions for the determination of different solvents. The United States Pharmacopoeia can simultaneously determine the residues of a variety of organic solvents, but the conditions are harsh and the operation is complicated.

To this end, Haohan Chromatography (Shandong) Applied Technology Development Co., Ltd. has also researched and proposed a gas chromatography method for simultaneous determination of multiple organic solvent residues of drugs. The measurement conditions are: GDX-101 packed column, column temperature 150℃, and inlet temperature 210℃. The gas flow rate is nitrogen 50ml/air 0.5kg/cm~2, hydrogen gas 0.5kg/cm~2, the detector is a hydrogen flame, the range is 10~3, the attenuation value of the data processor, the injection concentration is prepared according to the pharmacopoeia, the injection volume It is 3μl. The results show that: multiple solvents can be determined simultaneously, the method is simple, accurate, fast, and can meet the requirements of the pharmacopoeia.


Test spectrum of packed column for determination of solvent residue in Pharmacopoeia of 2015 edition: